Postnatally, heart muscle cells almost completely lose their ability to divide, which makes their loss after trauma irreversible. Potential repair by cell grafting or mobilizing endogenous cells is of particular interest for possible treatments for heart disease, where the poor capacity for cardiomyocyte proliferation probably contributes to the irreversibility of heart failure. Knowledge of the molecular mechanisms that underly formation of heart muscle cells might provide opportunities to repair the diseased heart by induction of (trans) differentiation of endogenous or exogenous (...) cells into heart muscle cells. We briefly review the molecular mechanisms involved in early development of the linear heart tube by differentiation of mesodermal cells into heart muscle cells. Because the initial heart tube does not comprise all the cardiac compartments present in the adult heart, heart muscle cells are added to the distal borders of the tube and within the tube. At both distal borders, mesodermal cell are recruited into the cardiac lineage and, within the heart tube, muscular septa are formed. In this review, the relative late additions of heart muscle cells to the linear heart tube are described and the potential underlying molecular mechanisms are discussed. BioEssays 26:248–261, 2004. Wiley Periodicals, Inc. (shrink)

This article is part of a For-Discussion-Section of Methods of Information in Medicine about the paper "Biomedical Informatics: We Are What We Publish", written by Peter L. Elkin, Steven H. Brown, and Graham Wright. It is introduced by an editorial. This article contains the combined commentaries invited to independently comment on the Elkin et al. paper. In subsequent issues the discussion can continue through letters to the editor.

Ethics for Enemies comprises three original philosophical essays on torture, terrorism, and war. F. M. Kamm deploys ethical theory in her challenging new treatments of these most controversial practical issues. First she considers the nature of torture and the various occasions on which it could occur, in order to determine why it might be wrong to torture a wrongdoer held captive, even if this were necessary to save his victims. In the second essay she considers what makes terrorism wrong--whether it (...) is the intention to harm civilians, rather than harm to them being 'collateral damage,' or something else--and whether terrorism is always wrong. The third essay discusses whether having a right reason, in the sense of a right intention, is necessary in order for a war to be just. Kamm then examines ways in which the harms of war can be proportional to the achievement of the just cause and other goods that war can bring about, so as to make the declaration of war permissible. (shrink)

The object of this paper is to show that, in the sixth and fifth centuries B.C., two different and radically opposed systems of thought were elaborated within the Pythagorean school. They may be called respectively the mystical system and the scientific. All current accounts of Pythagoreanism known to me attempt to combine the traits of both systems in one composite picture, which naturally fails to hold together. The confusion goes back to Aristotle, who usually speaks indiscriminately of ‘the Pythagoreans,’ though (...) now and then the phrase ‘some Pythagoreans’ indicates that he was aware of different currents within the school. (shrink)

It is well known that the medieval scholastics did not begin their philosophy systematically with an explicit theory of knowledge. Unfortunately many people have concluded from that fact that the very idea of an epistemology, and especially the idea of a critique of knowledge, was completely foreign to them. Within recent years authors such as Professor Van Steenberghen and Father Copleston have done a great deal to spread a correct understanding of St. Thomas’s views on this matter. Much evidence might (...) be adduced from the principal work of John Duns Scotus to show that he also took steps to justify man’s spontaneous conviction that some natural knowledge of truth with certainty can be attained. In this article we will consider some of these elements of Scotus’s philosophy as they are found in the volumes that have so far appeared in the critical edition of his works. (shrink)

Bioethical Prescriptions collects F.M. Kamm's articles on bioethics -- revised for publication in book form -- which have appeared over the last 25 years and which have made her among the most widely-respected philosophers working in this field.

Anaxagoras’ theory of matter offers a problem which, in bald outline, may be stated as follows. The theory rests on two propositions which seem flatly to contradict one another. One is the principle of Homoeomereity: A natural substance such as a piece of gold, consists solely of parts which are like the whole and like one another—every one of them gold and nothing else. The other is: ‘There is a portion of everything in everything’, understood to mean that a piece (...) of gold , so far from containing nothing but gold, contains portions of every other substance in the world. Unless Anaxagoras was extremely muddleheaded, he cannot have propounded a theory which simply consists of this contradiction. One or the other proposition must be reinterpreted so as to bring them into harmony. Some critics attack one, some the other; some try to modify both. Mr. C. Bailey has recently published a fresh attempt to reconstruct the theory in a form consistent with itself. But the result, as he admits, is arbitrary and uneconomical. These defects, like all the contradictions and obscurities found in other accounts of the system, can be traced to the second proposition: ‘There is a portion of everything in everything’, or rather to the construction put upon it. The language is crude, vague, and ambiguous. What does ‘everything’ mean? Has the first ‘everything’ the same sense as the second ? If taken to mean that there is a portion of every material substance in every material substance, the proposition leads to a result for which ‘uneconomical’ is an indulgent epithet. (shrink)

The object of this paper is to determine the relations between the two parts of Parmenides' poem: the Way of Truth, which deduces the necessary properties of a One Being, and the False Way, which contains a cosmogony based on ‘what seems to mortals, in which there is no true belief.’.

The earlier part of this paper yielded the result that the assertion ‘A portion of everything in everything’ has no place or function in the explanation of any sort of apparent ‘becoming’ or change. This conclusion is important because, ever since Aristotle, it has been assumed that the assertion was made in order to explain away becoming and change. But if , according to the best evidence, becoming and such sorts of change as Anaxagoras considered can be explained away without (...) using the assertion at all, it follows that the motive for it must be sought, not in the processes of apparent becoming and change, but in the permanent constitution of the ungenerated and unchanging things which figure as elements in the system. A visible mass of gold or of flesh is formed by the aggregation of smaller particles of gold or of flesh, and it is infinitely divisible into parts, every one of which is gold or flesh. But what is the constitution of a piece of gold of whatever size, and how does it differ from the constitution of a piece of flesh? The proposition we have so far successfully excluded comes in here as part of the answer to this question. (shrink)

The object of this paper is to determine the relations between the two parts of Parmenides' poem: the Way of Truth, which deduces the necessary properties of a One Being, and the False Way, which contains a cosmogony based on ‘what seems to mortals, in which there is no true belief.’.

I begin by reconsidering the arguments of John Taurek and Elizabeth Anscombe on whether the number of people we can help counts morally. I then consider arguments that numbers should count given by F. M. Kamm and Thomas Scanlon, and criticism of them by Michael Otsuka. I examine how different conceptions of the moral method known as pairwise comparison are at work in these different arguments and what the ideas of balancing and tie-breaking signify for decision-making in various types of (...) cases. I conclude by considering how another moral method that I call virtual divisibility functions and what it helps reveal about an argument by Otsuka against those who do not think numbers count. (shrink)

The October 2016 publication of the 2015 convegno on Peter of John Olivi begins with a fine survey of Provence and Languedoc in Olivi's time. J. Chiffoleau, with C. Lenoble, supplies the reader with much detail and some summary, along with abundant reference, on Olivi's home turf. In the come and go of life religious and lay, Olivi saw to critical support for business while trying to stabilize Franciscan life. He did very well by both. Chiffoleau finishes his pages on (...) Olivi's days by suggesting that Olivi had better to do around Narbonne than in Paris.Tiziana Suarez-Nani offers thoughts and examples of Peter Olivi's "spiritual philosophy". That he offers Aristotle little esteem we know; that Olivi... (shrink)

In the tenth study of his Quaestiones de perfectione evangelica,1 written in late 1279, Peter of John explained at length that, if engaged in spiritual pursuits, it is more perfect to beg for one’s sustenance than to acquire it by labor.2 To the study he tacked a second question.3 He considered critically the proposition that Franciscans owned nothing and did not touch money; they could live well, however, even very well, on the holdings of others.4 Brother Peter offered seven arguments (...) in favor of the proposal. Before he set each aside, however, he looked at six sections of Exiit qui seminat.5 With Exiit, he said, Pope Nicholas III confirmed all his past Studies as well as the present one.... (shrink)

This book is a philosophical discussion of moral, legal, and medical issues related to aging, dying, and death. One of its aims is to decide whether and when it might make sense to not resist or bring about the end of one's life. To answer this question it considers views about meaning in life and what makes life worth living. It also evaluates recent attempts to help the general public plan in advance for the end of life. It also considers (...) whether or not physician-assisted suicide is morally permissible and if it should be legalized. (shrink)

Zeller argued that the ‘innumerable worlds’ mentioned in accounts of Anaximander's system must be an endless succession of single worlds, not an unlimited number of coexistent worlds scattered through infinite space, some always coming into being while others are passing away. Zeller pointed out that a succession of single worlds is grounded in the principles of the system. ‘Things perish into that from which they had their birth… according to the order of Time,’ a cycle of birth, existence, and destruction. (...) A world ends, and the living divine stuff begets a new world to take its place. On the other hand, there is much in the system to contradict the idea of coexistent worlds. Anaximander's successors, Anaximenes, Anaxagoras, and Diogenes, show that this idea is not a necessary consequence of the unlimitedness of the original world-stuff. Nothing in the appearances of Nature suggests it. Anaximander is a monistic hylozoist, whereas Democritus is a pluralist with his innumerable independent atoms producing, by similar processes, independent world-systems in different parts of an infinite void. (shrink)

This article shows that core ideas of Hobbes's argument for civil authority have their sources in commentary on or texts of the Hebraic Bible. These ideas centre on the Hebraic idea of created nature and of man . It is further shown that both the eschatological and enlightenment components of Hobbes's philosophy originate in these same biblical ideas. Therefore, the often stressed and accustomed division of Leviathan into a secular and a religious teaching is mistakenly conceived.

The object of this paper is to show that, in the sixth and fifth centuries B.C., two different and radically opposed systems of thought were elaborated within the Pythagorean school. They may be called respectively the mystical system and the scientific. All current accounts of Pythagoreanism known to me attempt to combine the traits of both systems in one composite picture, which naturally fails to hold together. The confusion goes back to Aristotle, who usually speaks indiscriminately of ‘the Pythagoreans,’ though (...) now and then the phrase ‘some Pythagoreans’ indicates that he was aware of different currents within the school. (shrink)

This article considers the possible relation between the idea of parity and some past work on the allocation of scarce resources. Parity of value is first connected with the idea of some goods being irrelevant in interpersonal comparisons. The notion of moral parity is introduced to describe the recognition that people who are moral equals (even when they are not on a par in terms of value) as not substitutable. The relation between a Separability Test and nonsubstitutability of persons is (...) considered. These ideas are then used to discuss various cases in which one must choose to whom to provide medical assistance, including whether and when to distinguish morally between a disabled and a nondisabled person. (shrink)